Rhyl will welcome holders Cardiff Met in the Genero Adran Trophy following the draw for the Round of 16, made by Wales Women’s Hannah Cain.
The eight Genero Adran Premier sides were seeded in the draw, which sees Adran North leaders Connah’s Quay Nomads travel to Barry Town United and Cardiff City go to Briton Ferry whotop the Adran South.
Another all-south based tie sees Pontypridd United host Swansea University, while reigning Genero Adran Trophy champions Cardiff Met will visit Rhyl 1879.
Genero Adran Trophy Round of 16 draw
Barry Town United v Connah’s Quay Nomads
Swansea City v Llandudno
Wrexham v Abergavenny
Briton Ferry Llansawel v Cardiff City FC
Pontypridd United v Swansea University
Rhyl v Cardiff Met
Pontardawe Town or Cardiff Wanderers v Aberystwyth Town
Cascade v The New Saints
Ties to be played on Sunday 20 November.