After knocking out top-flight champions Swansea City, Genero Adran North side Llandudno head to Premier leaders Cardiff City FC.
Connah’s Quay Nomads – conquerors of Barry Town United in the round of 16 – will travel south again to take on the reigning Genero Adran Trophy champions Cardiff Met.
Wrexham thrashed higher division Abergavenny in the last round and will now make the trip to Aberystwyth Town.
The only all-top flight tie sees The New Saints take on Pontypridd United, after both sides knocked out Adran South opposition on Sunday.
Genero Adran Trophy quarter-final draw
Cardiff City FC v Llandudno
Cardiff Met v Connah’s Quay Nomads
Aberystwyth Town v Wrexham
The New Saints v Pontypridd United
All ties to be played on Sunday 15 January 2023.