Swansea University have been drawn away to Bute Energy Welsh Cup holders Cardiff City Women in the second round.
No Adran Premier Division sides were paired, in what was the last regionalised round before an open draw for the quarter-finals.
North Section
Rhyl v Aberystwyth Town
The New Saints v Felinheli
Wrexham v Llandudno
South Section
Pontardawe Town v Briton Ferry Llansawel
Pontypridd United v Cardiff Wanderers or Aberaman
Penybont v Cascade YC
Cardiff City Women v Swansea University
Cwmbran Celtic v Swansea City
Ties are to be played on Sunday 12 November, while it is back to league action this weekend …
Genero Adran League fixtures for Sunday 22 October (2pm)
Adran Premier
Aberystwyth Town v Wrexham (Park Avenue)
Pontypridd United v Cardiff City FC (USW Sports Park)
Barry Town United v Cardiff Met (Jenner Park Stadium)
The New Saints v Swansea City (Park Hall)
Adran North
Bangor v Llandudno (Nantporth Stadium)
Airbus UK Broughton v NFA (The Hollingsworth Group Stadium)
Connah’s Quay Nomads v Llanfair United (Holywell Town FC)
Rhyl v Felinheli (Belle Vue Stadium)
Adran South
Caldicot Town v Swansea University (Jubilee Way)
Cwmbran Celtic v Cascade (Celtic Park)
Briton Ferry Llansawel v Llanelli Town (Old Road Welfare Ground)
Pontardawe Town v Coed Duon (Parc Ynysderw)