Anna Moorhouse, Tessel Middag and Esmee de Graaf will leave West Ham United Women when their respective contracts expire this summer.
They are followed by centre-back Vyan Sampson, forward Ruesha Littlejohn and full-back Olivia Smith, says whufc.com.
Moorhouse made 24 appearances in all competitions across two seasons after joining from Arsenal, featuring in goal in the FA Cup Final last May.
Former Manchester City midfielder Middag missed the 2018/19 campaign due to injury but did make 19 appearances last season.
Winger De Graaf came from Dutch side Zwolle and despite suffering an ACL injury, played in 17 matches over two seasons.
Sampson played 19 times before being loaned to London City Lionesses, Littlejohn and Smith only joined midway through last season.