Manchester United and Arsenal take their Barclays Women’s Super League 100% records to Leicester City and Liverpool respectively.
But Spurs meet Manchester City in the weekend’s opening match on Saturday morning, Aston Villa then hosting Everton in a lunchtime fixture.
West Ham welcome Reading for a Sunday afternoon clash, before Brighton take on Chelsea in the evening kick-off.
Championship leaders Bristol City host Crystal Palace, holding a three-point advantage over both London City and Charlton, who visit Sunderland and Lewes respectively.
Birmingham City and Durham are level on points before their midday meeting, Sheffield United a point behind Southampton whom they host, Blackburn Rovers versus Coventry United is a battle of the bottom two.
Saturday 22 October
Tottenham Hotspur v Manchester City (Leyton Orient FC, 11:30am) – live on Sky Sports
Aston Villa v Everton (Walsall FC, 12:30) – live on The FA Player
Sunday 23 October
Liverpool v Arsenal (Tranmere Rovers FC, 12:00) – live on BBC Two/BBC iPlayer/BBC Sport Website
Leicester City v Manchester United (King Power Stadium, 3pm) – live on The FA Player
West Ham United v Reading (Dagenham & Redbridge FC, 3pm) – live on The FA Player
Brighton & Hove Albion v Chelsea (Crawley Town FC, 6:45pm) – live on Sky Sports
FA Women’s Championship
Birmingham City v Durham (St.Andrews, 12:00) – live on The FA Player
Sunderland v London City Lionesses (Eppleton Colliery Ground, 12:00)
Blackburn Rovers v Coventry United (Bamber Bridge FC, 2pm)
Lewes v Charlton Athletic (Lewes FC, 2pm)
Sheffield United v Southampton (Bramall Lane, 2pm)
Bristol City v Crystal Palace (Robins High Performance Centre, 3pm)