Last seasons runners-up, Swansea City, host Abergavenny (formerly PILCS) and third-placed Cardiff City FC take on Cwmbran Celtic, who finished fourth.
Cyncoed travel to mid-Wales to take on Aberystwyth Town and Llandudno welcome Port Talbot to Maesdu.
With 11 teams in the competition for next season, Rhyl have a free weekend.
All the fixtures for September:
04/09/2016 – Aberystwyth Town v Cyncoed, Cardiff City FC v Cwmbran Celtic, Cardiff Met v Briton Ferry Llansawel, Llandudno v Port Talbot Town, Swansea City v Abergavenny
11/09/2016 – Abergavenny v Aberystwyth Town, Briton Ferry Llansawel v Llandudno, Cwmbran Celtic v Rhyl, Cyncoed v Cardiff City FC, Port Talbot Town v Swansea City
18/09/2016 – Aberystwyth Town v Port Talbot Town, Cardiff City FC v Abergavenny, Llandudno v Cardiff Met, Rhyl v Cyncoed, Swansea City v Briton Ferry Llansawel
25/09/2016 – Abergavenny v Rhyl, Briton Ferry Llansawel v Aberystwyth Town, Cardiff Met v Swansea City, Cyncoed v Cwmbran Celtic, Port Talbot Town v Cardiff City FC
Source – welshpremierwomensleague.co.uk
