The Genero Adran Trophy Round of 16 draw has given holders Cardiff Met a home tie with tier-two team Coed Duon.
The Adran Premier sides were all seeded and entered at this stage, which will take place on Sunday 3 December.
Pontardawe Town face a testing trip to Adran Premier leaders Cardiff City Women, Llandudno have a big tie at home to Swansea City, while Wrexham host Briton Ferry Llansawel whom they beat in the promotion play-off last season.
Adran Trophy Round of 16 draw
The New Saints v Rhyl
Pontypridd United v Swansea University
Felinheli v Barry Town United
Connah’s Quay Nomads v Aberystwyth Town
Wrexham v Briton Ferry Llansawel
Llandudno v Swansea City
Cardiff City FC v Pontardawe Town
Cardiff Met v Coed Duon
Attention now turns to the Bute Energy Wales Cup 2nd Round this Sunday, 12 November (2pm kick-offs).
Rhyl v Aberystwyth Town (Belle Vue Stadium)
The New Saints v Felinheli (Park Hall)
Wrexham v Llandudno (The Rock)
Pontardawe Town v Briton Ferry Llansawel (Parc Ynysderw)
Pontypridd United v Aberaman (USW Sports Park)
Penybont v Cascade YC (Penybont FC, 12.20pm)
Cardiff City Women v Swansea University (Cardiff International Sports Stadium)
Cwmbran Celtic v Swansea City (Celtic Park)
Adran North
Llanfair United v Bangor (Mount Field)
