Midweek ties in the FA Women’s Continental Tyres League Cup feature Liverpool against Manchester United and Championship side Southampton taking on Arsenal.
Durham lead Group A with five points and host Sheffield United, Aston Villa will look to continue a winning start at home to Blackburn Rovers.
Manchester City have won both their games in Group B and are home to Leicester City, who have begun with a victory. Manchester United also started with three points and visit a Liverpool side who have lost twice.
Both matches in Group C so far have gone to shoot-outs, with Watford and Lewes winning the bonus points. While the Hornets go to Crystal palace next, the Rooks welcome London City Lionesses for the second time in a week after a 2-1 Championship result over them on Sunday.
Southampton are top of Group D with five points, visitors Arsenal and also Tottenham are on three points with a game in hand, Spurs hosting Bristol City.
Brighton and West Ham meet in Group E with three points apiece, Charlton Athletic host Birmingham City as both teams hope to get off the mark.
Meanwhile on Thursday, Chelsea play Paris FC at Stamford Bridge (KO 8pm) in the UEFA Women’s Champions League Group Stage, live on TNT Sports 1, DAZN and DAZN Women’s Football YouTube channel.
Wednesday 22 November
Group A – Aston Villa v Blackburn Rovers (Walsall FC, 7pm)
Group B – Liverpool v Manchester United (Tranmere Rovers FC, 7pm) – live on MUTV/The FA Player, Manchester City v Leicester City (Joie Stadium, 7pm)
Group C – Crystal Palace v Watford (Sutton Utd FC, 7.15pm), Lewes v London City Lionesses (Lewes FC, 7.30pm)
Group D – Tottenham Hotspur v Bristol City (Leyton Orient FC, 7.30pm)
Group E – Charlton Athletic v Birmingham City (VCD Athletic, 7pm), Brighton & Hove Albion v West Ham United (Crawley Town FC, 7pm)
Thursday 23 November
Group A – Durham v Sheffield United (Maiden Castle, 7pm)
Group D – Southampton v Arsenal (Southampton FC, 6.30pm)